self-administration
Oct. 30th, 2007 12:03 am![[identity profile]](https://www.dreamwidth.org/img/silk/identity/openid.png){kind=small}
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ru_translateНарод, подскажите кто может, что-то я совсем отупел:
The intravenous self-administration liability of smthcyclin was evaluated in 2 studies in rhesus monkeys. In the first study, monkeys had a self-administration baseline of 24-hour access to smthmonal. Smthcyclin (1, 2, 4, or 8 mg/kg/injection) was substituted for smthmonal for a period of at least 14 days/dose. Positive reinforcement was prospectively defined in this study as 10 or more injections/day for 7 consecutive days. By this definition, none of the animals self-administered smthcyclin at any dose tested, indicating a lack of reinforcing effect.
Это что имеется в виду? Что макаки сами себе внутривенно smthcyclin кололи?
Бред какой-то.
Подскажите.
Спасибо
The intravenous self-administration liability of smthcyclin was evaluated in 2 studies in rhesus monkeys. In the first study, monkeys had a self-administration baseline of 24-hour access to smthmonal. Smthcyclin (1, 2, 4, or 8 mg/kg/injection) was substituted for smthmonal for a period of at least 14 days/dose. Positive reinforcement was prospectively defined in this study as 10 or more injections/day for 7 consecutive days. By this definition, none of the animals self-administered smthcyclin at any dose tested, indicating a lack of reinforcing effect.
Это что имеется в виду? Что макаки сами себе внутривенно smthcyclin кололи?
Бред какой-то.
Подскажите.
Спасибо
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no subject
Date: 2007-10-29 09:08 pm (UTC)just a guess.
no subject
Date: 2007-10-29 09:15 pm (UTC)To shed some light...
Date: 2007-10-29 10:22 pm (UTC)-- Intravenous Self-Administration Lab
Quote:
Each rat had a small stainless steel tube permanently mounted on its head that permitted connection of its intravenous catheter to the infusion line with a minimum of restrain. Contrary to popular belief, the rats 'enjoy' participating in these experiments and willingly remain immobile while they are being connected to the infusion line for testing.
Operant chambers contained two levers and two cue lights for programming various experimental contingencies. Drug infusions were delivered by computer activation of a stepping motor on a syringe pump (shown here disconnected for sterilization of the infusion line). Computer programs were written for conducting studies using simple reinforcement schedules and for complex progressive-ratio testing.
Click here (http://www.addictionscience.net/rat_ivsa.mpg) for a brief video (1.36 MB MPEG) of a rat pressing for cocaine injections on an intermittent reinforcement schedule.
Source - http://wings.buffalo.edu/aru/IVSAfacilities.htm
no subject
Date: 2007-10-30 12:21 am (UTC)Возможно и другая формулировака, но коротко чаще встречается именно этот термин.
Пример (немного о другом, но именно на в этих моделях чаще используется):
http://www.soramn.ru/Journal/2004/N3/chapt12/2.pdf
no subject
Date: 2007-10-30 01:13 am (UTC)но пенгвин и звуву пролили свет
спс